Structure of PDB 6jbj Chain A

Receptor sequence
>6jbjA (length=565) Species: 9606 (Homo sapiens) [Search protein sequence]
RPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGL
IPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWR
KDLTEHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMAS
KLIISPFTLVYYTYQCFQSTGWLGPVSIFGYFILGTVVNKTLMGPIVMKL
VHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRTDRRLQRLLQTQRE
LMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSK
NAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLDTAFLL
ERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWT
STRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSAD
DERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFY
LQPKYAVLDQATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLV
LKLCGGGRWELMRIK
3D structure
PDB6jbj Cryo-EM structure of human lysosomal cobalamin exporter ABCD4.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.8: ABC-type vitamin B12 transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A T423 G424 G426 K427 T428 R432 W438 Q461 T384 G385 G387 K388 T389 R393 W399 Q422
BS02 ATP A R508 D522 V523 S525 E528 R469 D483 V484 S486 E489
Gene Ontology
Molecular Function
GO:0005324 long-chain fatty acid transmembrane transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015420 ABC-type vitamin B12 transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042802 identical protein binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0007031 peroxisome organization
GO:0009235 cobalamin metabolic process
GO:0015889 cobalamin transport
GO:0015910 long-chain fatty acid import into peroxisome
GO:0042760 very long-chain fatty acid catabolic process
GO:0055085 transmembrane transport
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jbj, PDBe:6jbj, PDBj:6jbj
PDBsum6jbj
PubMed31467407
UniProtO14678|ABCD4_HUMAN Lysosomal cobalamin transporter ABCD4 (Gene Name=ABCD4)

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