Structure of PDB 6j9j Chain A

Receptor sequence

>6j9jA (length=247) Species: 9606 (Homo sapiens)

PSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERAMQCECTPLSK
DERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVIL
TEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLV
PSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGK

3D structure

• PDB: 6j9j Histone H3.3 phosphorylation amplifies stimulation-induced transcription.
• Chain: A
• Resolution: 1.78 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y1579 F1589 Y1604 F1606 M1607 A1608 E1636 T1637 T1653 D1665 Y1666 Q1667 F1668 Q1669 R1670 Y1671 G1672 K1673 E1674 A1700	Y123 F133 Y148 F150 M151 A152 E180 T181 T197 D209 Y210 Q211 F212 Q213 R214 Y215 G216 K217 E218 A244
BS02	ZN	A	C1499 C1501 C1516 C1520	C43 C45 C60 C64
BS03	ZN	A	C1516 C1529 C1533 C1539	C60 C73 C77 C83
BS04	ZN	A	C1631 C1678 C1680 C1685	C175 C222 C224 C229
BS05	SAH	A	K1560 G1561 W1562 H1603 Y1604 Y1605 R1625 F1626 N1628 H1629 Y1666 Q1676 C1678 F1679	K104 G105 W106 H147 Y148 Y149 R169 F170 N172 H173 Y210 Q220 C222 F223

Gene Ontology

Molecular Function

• GO:0016279 protein-lysine N-methyltransferase activity
• GO:0042054 histone methyltransferase activity
• GO:0046975 histone H3K36 methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:6j9j, PDBe:6j9j, PDBj:6j9j
• PDBsum: 6j9j
• PubMed: 32699416
• UniProt: Q9BYW2|SETD2_HUMAN Histone-lysine N-methyltransferase SETD2 (Gene Name=SETD2)