Structure of PDB 6j5w Chain A

Receptor sequence

>6j5wA (length=816) Species: 3702 (Arabidopsis thaliana)

MVDAVVTVFLEKTLNILEEKGRTVSDYRKQLEDLQSELKYMQSFLKDAER
QKRTNETLRTLVADLRELVYEAEDILVDCQLADGDDGNEQRSSNAWLSRL
HPARVPLQYKKSKNGTDRWSSPVYDHTQVVGLEGDKRKIKEWLFRSNDSQ
LLIMAFVGMGGLGKTTIAQEVFNDKEIEHRFERRIWVSVSQTFTEEQIMR
SILRNLGDASVGDDIGTLLRKIQQYLLGKRYLIVMDDVWDKNLSWWDKIY
QGLPRGQGGSVIVTTRSESVAKRVQARDDKTHRPELLSPDNSWLLFCNVA
FAANDGTCERPELEDVGKEIVTKCKGLPLTIKAVGGLLLCKDHVYHEWRR
IAEHFQDELRGNTSETDNVMSSLQLSYDELPSHLKSCILTLSLYPEDCVI
PKQQLVHGWIGEGFVMWRNGRSATESGEDCFSGLTNRCLIEVVDKTYSGT
IITCKIHDMVRDLVIDIAKKDSFSNPEGLNCRHLGISGNFDEKQIKVNHK
LRGVVSTTKTGEVNKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDE
IASLQHLACLSLSNTHPLIQFPRSMEDLHNLQILDASYCQNLKQLQPCIV
LFKKLLVLDMTNCGSLECFPKGIGSLVKLEVLLGFKPARSNNGCKLSEVK
NLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCYDSYGDDLITK
IDALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMSICSGNLVKMQE
PFWGNENTHWRIEGLMLSSLSDLDMDWEVLQQSMPYLRTVTANWCPELES
FAIEDVGFRGGVWMKT

3D structure

• PDB: 6j5w Ligand-triggered allosteric ADP release primes a plant NLR complex.
• Chain: A
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	V161 L163 G192 G194 K195 T196 T197 L326 P359 K363 H488	V130 L132 G161 G163 K164 T165 T166 L295 P328 K332 H457

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0005515 protein binding
• GO:0043531 ADP binding

Biological Process

• GO:0006952 defense response
• GO:0042742 defense response to bacterium
• GO:0050776 regulation of immune response
• GO:0050829 defense response to Gram-negative bacterium
• GO:0051707 response to other organism

Cellular Component

• GO:0005634 nucleus
• GO:0005886 plasma membrane

External links

• PDB: RCSB:6j5w, PDBe:6j5w, PDBj:6j5w
• PDBsum: 6j5w
• PubMed: 30948526
• UniProt: Q38834|R13L4_ARATH Disease resistance RPP13-like protein 4 (Gene Name=RPP13L4)