Structure of PDB 6j5l Chain A

Receptor sequence
>6j5lA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
SGIRVHHIKRRDIVLKWELGEGAFGKVFLAECHNLDKMLVAVKALKEASE
SARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL
RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGIYSTDYYRVTMLPIRWMPPESILYRKFTTES
DVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYA
IMRGCWQREPQQRHSIKDVHARLQALAQAPPV
3D structure
PDB6j5l The discovery of novel 3-aryl-indazole derivatives as peripherally restricted pan-Trk inhibitors for the treatment of pain.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D650 R654 N655 D668
Catalytic site (residue number reindexed from 1) D149 R153 N154 D167
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B9C A L516 G517 F521 V524 A542 Y591 M592 G595 R654 L657 L19 G20 F24 V27 A41 Y90 M91 G94 R153 L156 MOAD: ic50=1.6nM
PDBbind-CN: -logKd/Ki=8.80,IC50=1.6nM
BindingDB: IC50=1.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6j5l, PDBe:6j5l, PDBj:6j5l
PDBsum6j5l
PubMed31235262
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

[Back to BioLiP]