Structure of PDB 6j51 Chain A

Receptor sequence
>6j51A (length=1411) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVFKHI
SPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLTH
KLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQA
LQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQV
GVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRID
LRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMP
YSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSP
QSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPA
ILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMF
GVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFSI
GIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESF
EGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSAC
VGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFF
FHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDII
QFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVIE
YAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRRI
IQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQN
ATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEM
VGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIAL
DIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSQ
SPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLII
RCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEYK
NEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSLY
KEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALMR
CSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEKL
LTSLPADYAPT
3D structure
PDB6j51 Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
ChainA
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A A252 M253 Y418 D486 A237 M238 Y403 D471
BS02 dna A K318 K333 R345 A833 R1389 K303 K318 R330 A818 R1337
BS03 ZN A C67 C70 H80 C66 C69 H79
BS04 ZN A N109 C110 C168 N108 C109 C157
BS05 MG A D482 D484 D486 D467 D469 D471
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j51, PDBe:6j51, PDBj:6j51
PDBsum6j51
PubMed30733384
UniProtC4R4Y0

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