Structure of PDB 6j3p Chain A

Receptor sequence
>6j3pA (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
DPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTM
TERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFK
LKEGGLID
3D structure
PDB6j3p Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
ChainA
Resolution1.598 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B8O A W751 P752 V757 E761 N808 Y814 W23 P24 V29 E33 N80 Y86 MOAD: Kd=105nM
PDBbind-CN: -logKd/Ki=6.98,Kd=105nM
BindingDB: Kd=105nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6j3p, PDBe:6j3p, PDBj:6j3p
PDBsum6j3p
PubMed30998845
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

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