Structure of PDB 6j1l Chain A

Receptor sequence
>6j1lA (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWE
MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRM
CRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSED
EIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLEKTHRQSILAK
LPPKGKLRSLCSQHVERLQIFQ
3D structure
PDB6j1l Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B6L A Q286 L287 C320 L324 R364 M365 R367 A368 F377 L391 L396 H479 Q21 L22 C55 L59 R99 M100 R102 A103 F112 L126 L131 H214 PDBbind-CN: -logKd/Ki=6.42,Kd=380nM
BindingDB: IC50=750nM,Kd=380nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j1l, PDBe:6j1l, PDBj:6j1l
PDBsum6j1l
PubMed30964293
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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