Structure of PDB 6izq Chain A

Receptor sequence
>6izqA (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
SAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCG
SGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEE
VSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL
APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFD
IRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVA
FIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANK
RQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY
3D structure
PDB6izq Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
ChainA
Resolution2.449 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XJ2 A F152 Y153 Q158 M162 E257 M259 Y261 E266 M268 H414 W415 F8 Y9 Q14 M18 E113 M115 Y117 E122 M124 H270 W271 MOAD: ic50=3.19uM
PDBbind-CN: -logKd/Ki=5.50,IC50=3.19uM
BindingDB: IC50=3190nM
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6izq, PDBe:6izq, PDBj:6izq
PDBsum6izq
PubMed31117515
UniProtQ86X55|CARM1_HUMAN Histone-arginine methyltransferase CARM1 (Gene Name=CARM1)

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