Structure of PDB 6iy9 Chain A

Receptor sequence
>6iy9A (length=325) Species: 1912 (Streptomyces hygroscopicus) [Search protein sequence]
QESLLLLDRIDSDDSYASLRNDQEFWEPLARRALEELGLPVPPVLRVPGE
STNPVLVGEPGPVIKLFGEHWCGPESLASESEAYAVLADAPVPVPRLLGR
GELRPGTGAWPWPYLVMSRMTGTTWRSAMDGTTDRNALLALARELGRVLG
RLHRVPLTGNTVLTPHSEVFPELLRERRAATVEDHRGWGYLSPRLLDRLE
DWLPDVDTLLAGREPRFVHGDLHGTNIFVDLAATEVTGIVDFTDVYAGDS
RYSLVQLHLNAFRGDREILAALLDGAQWKRTEDFARELLAFTFLHDFEVF
EETPLDLSGFTDPEELAQFLWGPPD
3D structure
PDB6iy9 Structural basis for the substrate recognition of aminoglycoside 7''-phosphotransferase-Ia from Streptomyces hygroscopicus.
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.119: hygromycin-B 7''-O-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HY0 A W73 C74 E77 S78 D246 D298 F299 E300 W71 C72 E75 S76 D244 D296 F297 E298
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008904 hygromycin-B 7''-O-phosphotransferase activity
GO:0016301 kinase activity
Biological Process
GO:0016310 phosphorylation
GO:0046677 response to antibiotic

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6iy9, PDBe:6iy9, PDBj:6iy9
PDBsum6iy9
PubMed31475927
UniProtP09979|KHYB_STRHY Hygromycin-B 7''-O-kinase (Gene Name=hyg)

[Back to BioLiP]