Structure of PDB 6ixx Chain A

Receptor sequence

>6ixxA (length=463) Species: 686394 (Flavobacterium sp. YS-80-122)

ANGTSSAFTQVDNFSHFYDRGNHLVNGKPSFTVDQAADQLTRSGASWYDL
NGDGVINLSYTFLTSPPPGYASRGLGTFSSFSGLQKEQAKLSLESWADVA
KVTFTEGPAARGDDGHMTFANFSASNGGAAFAYLPNSSRKGESWYLINKD
YDVNKTPGEGNYGRQTLTHEIGHTLGLSHPGDYNAGNGNPSYRDAVYGED
TRAYSVMSYWSEKNTGQVFTKTGEGAYASAPLLDDIAAVQKLYGANMETR
AGDTVYGFNSTADRDYYSATSATDKLIFSVWDGGGNDTLDFSGFSQNQKI
NLAAGSFSDVGGMTGNVSIAQGVTIENAIGGSGNDLLLGNAASNILKGGA
GNDIIYGGGGADKLWGGSGSDTFVYREVSDSTPKAADTLMDFQTGLDKID
LTGITHLSGLNFVNAFTGQAGDAVVSYNQASNAGSLQVDFSGHGVADFLI
TTVGQVATYDIVA

3D structure

• PDB: 6ixx Crystal structure of a complex between psychrophilic marine protease MP and its inhibitor LupI
• Chain: A
• Resolution: 1.999 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	G366 A367 G368 D370 G383 G384 S385 D388	G349 A350 G351 D353 G366 G367 S368 D371
BS02	CA	A	N357 A359 N361 G374 G376 D379	N340 A342 N344 G357 G359 D362
BS03	CA	A	G348 G350 D352 G365 A367 D370	G331 G333 D335 G348 A350 D353
BS04	CA	A	G375 G376 G377 D379 D397 D404	G358 G359 G360 D362 D380 D387
BS05	CA	A	G384 S385 G386 D388 Q410 D414	G367 S368 G369 D371 Q393 D397
BS06	CA	A	R267 G269 T271 D299 G301 D304	R250 G252 T254 D282 G284 D287
BS07	CA	A	G302 D304 T341 E343	G285 D287 T324 E326
BS08	CA	A	D66 N68 D70 V72 N74 D131	D49 N51 D53 V55 N57 D114
BS09	ZN	A	H186 H190 H196	H169 H173 H179

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0005509 calcium ion binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0031012 extracellular matrix

External links

• PDB: RCSB:6ixx, PDBe:6ixx, PDBj:6ixx
• PDBsum: 6ixx
• UniProt: D0VMS8