Structure of PDB 6iw6 Chain A

Receptor sequence
>6iw6A (length=438) Species: 9606 (Homo sapiens) [Search protein sequence]
EMDYLENATVIDESALTPEQRLGLKQAEERLERDHIFRLEKRSPEYTNCR
YLCKLCLIHIENIQGAHKHIKEKRHKKNILEKQEESELRSLPPPSPAHLA
ALSVAVIELAKEHGITDDDLRVRQEIVEEMSKVITTFLPECSLRLYGSSL
TRFALKSSDVNIDIKFPPKMNHPDLLIKVLGILKKNVLYVDVESDFHAKV
PVVVCRDRKSGLLCRVSAGNDMACLTTDLLTALGKIEPVFIPLVLAFRYW
AKLCYIDSQTDGGIPSYCFALMVMFFLQQRKPPLLPCLLGSWIEGFDPKR
MDDFQLKGIVEEKFVKWECNSSSATKEKHGKSPLALETPNRVSLGQLWLE
LLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIEDPFSVKRNVAR
SLNSQLVYEYVVERFRAAYRYFACPQVDFKLEHHHHHH
3D structure
PDB6iw6 Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression.
ChainA
Resolution2.402 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C306 C309 H322 H328 C53 C56 H69 H75
BS02 ZN A C507 H726 H728 H730 C254 H433 H435 H437
Gene Ontology
Molecular Function
GO:0016779 nucleotidyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6iw6, PDBe:6iw6, PDBj:6iw6
PDBsum6iw6
PubMed31036859
UniProtQ5TAX3|TUT4_HUMAN Terminal uridylyltransferase 4 (Gene Name=TUT4)

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