Structure of PDB 6iv6 Chain A

Receptor sequence

>6iv6A (length=1209) Species: 386891 (Moraxella bovoculi)

MLFQDFTHLYPLSKTVRFELKPIGKTLEHIHAKNFLNQDETMADMYQKVK
AILDDYHRDFIADMMGEVKLTKLAEFYDVYLKFRKNPKDDGLQKQLKDLQ
AVLRKEIVKPIGNGGKYKAGYDRLFGAKLFKDGKELGDLAKFVIAQEGES
SPKLAHLAHFEKFSTYFTGFHDNRKNMYSDEDKHTAIAYRLIHENLPRFI
DNLQILATIKQKHSALYDQIINELTASGLDVSLASHLDGYHKLLTQEGIT
AYNTLLGGIQGINELINSHHNQHSERIAKLRPLHKQISKFADDSEVCQAV
NEFYRHYADVFAKVQSLFDGFDDYQKDGIYVEYKNLNELSKQAFGDFALL
GRVLDGYYVDVVNPEFNASLEQAIEHYTARHDDESVQAGKLGQYFKHGLA
GVDNPIQKIHNNHSTIKGFLERERPAGERALPKIKSDKSPEIRQLKELLD
NALNVAHFAKLLTTKTTLHNQDGNFYGEFGALYDELAKIATLYNKVRDYL
SQKPFSTEKYKLNFGNPTLLNGWDLNKEKDNFGVILQKDGCYYLALLDKA
HKKVFDNAPNTGKSVYQKMIYKLLPGPNKMLPKVFFAKSNLDYYNPSAEL
LDKYAQGTHKKGDNFNLKDCHALIDFFKAGINKHPEWQHFGFKFSPTSSY
QDLSDFYREVEPQGYQVKFVDINADYINELVEQGQLYLFQIYNKDFSPKA
HGKPNLHTLYFKALFSEDNLVNPIYKLNGEAEIFYRKASLDMNETTIHRA
GEVLENKNPDNPKKRQFVYDIIKDKRYTQDKFMLHVPITMNFGVQGMTIK
EFNKKVNQSIQQYDEVNVIGIDRGERHLLYLTVINSKGEILEQRSLNDIT
TASANGTQMTTPYHKILDKREIERLNARVGWGEIETIKELKSGYLSHVVH
QISQLMLKYNAIVVLEDLNFGFKRGCFKVEKQIYQNFENALIKKLNHLVL
KDKADDEIGSYKNALQLTNNFTDLKSIGKQTGFLFYVPAWNTSKIDPETG
FVDLLKPRYENIAQSQAFFGKFDKICYNADRGYFEFHIDYAKFNDKAKNS
RQIWKICSHGDKRYVYDKTANQNKGATIGVNVNDELKSLFTRYHINDKQP
NLVMDICQNNDKEFHKSLMYLLKTLLALRYSNASSDEDFILSPVANDEGV
FFNSALADDTQPQNADANGAYHIALKGLWLLNELKNSDDLNKVKLAIDNQ
TWLNFAQNR

3D structure

• PDB: 6iv6 An anti-CRISPR protein disables type V Cas12a by acetylation.
• Chain: A
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	S13 K14 T15 R17 F18 E19 Y46 F170 N173 N745 K746 K751 H753 G754 K755 N757 H759 F786 R788 H800 L806 E807 N808 K809 N810 K815 R817 F819 V820 Y821 I824 K825 K827 R828 Y829 H837 A904 Y915 E941 G945 S948 H949 H952 K996 K1003	S13 K14 T15 R17 F18 E19 Y46 F170 N173 N693 K694 K699 H701 G702 K703 N705 H707 F734 R736 H748 L754 E755 N756 K757 N758 K763 R765 F767 V768 Y769 I772 K773 K775 R776 Y777 H785 A852 Y863 E889 G893 S896 H897 H900 K944 K951

External links

• PDB: RCSB:6iv6, PDBe:6iv6, PDBj:6iv6
• PDBsum: 6iv6
• PubMed: 30936526