Structure of PDB 6iuo Chain A

Receptor sequence
>6iuoA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMARPD
QASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGP
LYVIVECAAKGNLREFLRARRPPGPLSFPVLVSCAYQVARGMQYLESRKC
IHRDLAARNVLVTEDNVMKIADFGLLPVKWMAPEALFDEVYTHQSDVWSF
GILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMREC
WHAAPSQRPTFKQLVEALDKVLLAV
3D structure
PDB6iuo Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 R616 N617 D630
Catalytic site (residue number reindexed from 1) D154 R158 N159 D172
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AWX A C477 Q480 V481 A501 E520 V550 C552 A553 L619 C34 Q37 V38 A56 E75 V105 C107 A108 L161 PDBbind-CN: -logKd/Ki=7.79,IC50=16.3nM
BindingDB: IC50=>200nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6iuo, PDBe:6iuo, PDBj:6iuo
PDBsum6iuo
PubMed31335138
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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