Structure of PDB 6iu7 Chain A

Receptor sequence

>6iu7A (length=422) Species: 10090 (Mus musculus) [Search protein sequence]

NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYF

3D structure

PDB

6iu7 Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	S105 F138 W142 N146 S149 G150 T151 T155 Q181 W184 N188 G191 D192 W231 R238 D270 W273 Y277 G281 R315 V321 T322 W357 N361 E396 W399	S31 F64 W68 N72 S75 G76 T77 T81 Q107 W110 N114 G117 D118 W157 R164 D196 W199 Y203 G207 R241 V247 T248 W283 N287 E322 W325

External links

PDB	RCSB:6iu7, PDBe:6iu7, PDBj:6iu7
PDBsum	6iu7
PubMed	30685087
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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