Structure of PDB 6itv Chain A

Receptor sequence
>6itvA (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAM
TVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLV
ITEYCCYGDLLNFLRRKRDSEDDELALDLEDLLSFSYQVAKGMAFLASKN
CIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMA
PESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGF
RMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHI
3D structure
PDB6itv Crystal structure of activated c-KIT in complex with compound
ChainA
Resolution1.881 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D792 R796 N797 D810
Catalytic site (residue number reindexed from 1) D155 R159 N160 D173
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AWO A L595 A621 K623 E640 L644 T670 Y672 C673 G676 L799 I808 C809 D810 F811 L27 A53 K55 E72 L76 T102 Y104 C105 G108 L162 I171 C172 D173 F174
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6itv, PDBe:6itv, PDBj:6itv
PDBsum6itv
PubMed
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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