Structure of PDB 6itt Chain A

Receptor sequence
>6ittA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
INGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLI
KSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTI
GGPTLVITEYCCYGDLLNFLRRKRDSEDDELALDLEDLLSFSYQVAKGMA
FLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARL
PVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYK
MIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISES
T
3D structure
PDB6itt Crystal structure of unactivated c-KIT in complex with compound
ChainA
Resolution2.103 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D792 R796 N797 D810
Catalytic site (residue number reindexed from 1) D161 R165 N166 D179
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AWO A L595 K623 E640 T670 Y672 C673 G676 L783 L799 C809 D810 F811 L33 K61 E78 T108 Y110 C111 G114 L152 L168 C178 D179 F180
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6itt, PDBe:6itt, PDBj:6itt
PDBsum6itt
PubMed
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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