Structure of PDB 6iqw Chain A

Receptor sequence

>6iqwA (length=771) Species: 523850 (Thermococcus onnurineus NA1)

MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEY
ELLSLFSEFHHKGHMKNDELMIRRIKELSPERFGLTMEDVLNALWIVYEA
DNLASGPQASRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRE
LVKRLWEELSKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTS
AIALAMLRAGCTAEDVRSGRCRKEKRFLLIEGDFSGIQDFIYRVSGKGTL
KYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDA
VKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGKNLFAEAR
KRLKHKLTVRKLKRFGEIKGLFEHGHTERLAECPVCGRELPEGKLEPSAS
DPETKVCPTCNRLVSLGGNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQ
GGRPVGEQILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEELS
MASTGTRRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAI
IEGKFGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRV
RRAFNAYTGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVF
VVGRSRPLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLL
WKLLEIRELYVRDPNDVRWAYLTAYLLGRHGLSDLFPELVGIDTKAVERK
EPQPVYWVDGVLKIVLMAVRR

3D structure

• PDB: 6iqw Cryo-EM structure of Type III-A CRISPR effector complex.
• Chain: A
• Resolution: 3.35 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	F290 H295 D521 R524 L525 G526 F529 S542 G587 D588 R652	F284 H289 D515 R518 L519 G520 F523 S536 G581 D582 R646

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity
• GO:0004527 exonuclease activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016740 transferase activity
• GO:0042802 identical protein binding

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:6iqw, PDBe:6iqw, PDBj:6iqw
• PDBsum: 6iqw
• PubMed: 30459428
• UniProt: B6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)