Structure of PDB 6ip2 Chain A

Receptor sequence
>6ip2A (length=520) Species: 10029 (Cricetulus griseus) [Search protein sequence]
EKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCG
KTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRR
LGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLN
NILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMR
GHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEV
DMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVT
RVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFI
KICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIG
PRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTI
HVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIE
MSLQMDPEYRVRKFLALLRE
3D structure
PDB6ip2 Mechanistic insights into the SNARE complex disassembly.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G263 C264 G265 K266 T267 L268 A439 E442 G48 C49 G50 K51 T52 L53 A224 E227
BS02 ATP A N505 G506 I507 I508 H546 S547 G548 K549 T550 A551 L552 N290 G291 I292 I293 H331 S332 G333 K334 T335 A336 L337
Gene Ontology
Molecular Function
GO:0000149 SNARE binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017075 syntaxin-1 binding
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030165 PDZ domain binding
GO:0035255 ionotropic glutamate receptor binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0140545 ATP-dependent protein disaggregase activity
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0006813 potassium ion transport
GO:0006886 intracellular protein transport
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0035494 SNARE complex disassembly
GO:0043001 Golgi to plasma membrane protein transport
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030496 midbody

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ip2, PDBe:6ip2, PDBj:6ip2
PDBsum6ip2
PubMed30989110
UniProtP18708|NSF_CRIGR Vesicle-fusing ATPase (Gene Name=NSF)

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