Structure of PDB 6in0 Chain A

Receptor sequence
>6in0A (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
AKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK
QRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR
KHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKV
SDFGLSRVLIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYW
EMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVS
ILDKLIRNPGSLKIITSSNLLL
3D structure
PDB6in0 Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
ChainA
Resolution1.501 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D746 R750 N751 D764
Catalytic site (residue number reindexed from 1) D134 R138 N139 D152
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O4B A K653 E670 M674 I697 K41 E58 M62 I85
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6in0, PDBe:6in0, PDBj:6in0
PDBsum6in0
PubMed
UniProtP29320|EPHA3_HUMAN Ephrin type-A receptor 3 (Gene Name=EPHA3)

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