Structure of PDB 6ime Chain A

Receptor sequence
>6imeA (length=285) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
NFPQLPPAPDDYPTFPDTSTWPVVFPELPAAPYGGPCRPPQHTSKAAAPR
IPADRLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVIDIACGAIELG
IKWLSLYAFSTENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWVG
SRPRLWRSVINELAVAEEMTKSNDVITINYCVNYGGRTEITEATREIARE
VAAGRLNPERITESTIARHLQRPDIPDVDLFLRTSGEQRSSNFMLWQAAY
AEYIFQDKLWPDYDRRDLWAACEEYASRTRRFGSA
3D structure
PDB6ime Substrate-analogue complex structure of Mycobacterium tuberculosis decaprenyl diphosphate synthase.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.86: trans,polycis-decaprenyl diphosphate synthase.
2.5.1.87: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GST A M75 D76 G77 G79 R80 R89 H93 A119 R127 M64 D65 G66 G68 R69 R78 H82 A108 R116
BS02 MG A Y261 G294 Y250 G283
BS03 ISY A R292 G294 R281 G283
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004659 prenyltransferase activity
GO:0008834 di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030145 manganese ion binding
GO:0033850 Z-farnesyl diphosphate synthase activity
GO:0045547 dehydrodolichyl diphosphate synthase activity
GO:0046872 metal ion binding
GO:0052923 all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
Biological Process
GO:0016094 polyprenol biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ime, PDBe:6ime, PDBj:6ime
PDBsum6ime
PubMed30950820
UniProtP9WFF7|DPDS_MYCTU Decaprenyl diphosphate synthase (Gene Name=uppS)

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