Structure of PDB 6ilz Chain A

Receptor sequence
>6ilzA (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
FDLLRVIGRGSYAKVLLVRLDRIYAMKVVKKELVNDDEDIDWVQTEKHVF
EQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHAR
FYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRP
GDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIE
DYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQ
GHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD
DDIVRKIDQSEFEGFEYINP
3D structure
PDB6ilz Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.
ChainA
Resolution3.261 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D378 K380 N383 D396 T416
Catalytic site (residue number reindexed from 1) D122 K124 N127 D140 T160
Enzyme Commision number 2.7.11.13: protein kinase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AFU A I260 Y334 T395 D396 F552 D553 I7 Y78 T139 D140 F285 D286 PDBbind-CN: -logKd/Ki=6.47,IC50=0.34uM
BindingDB: IC50=340nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007163 establishment or maintenance of cell polarity

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Molecular Function
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Biological Process
External links
PDB RCSB:6ilz, PDBe:6ilz, PDBj:6ilz
PDBsum6ilz
PubMed30891133
UniProtP41743|KPCI_HUMAN Protein kinase C iota type (Gene Name=PRKCI)

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