Structure of PDB 6ilh Chain A

Receptor sequence
>6ilhA (length=502) Species: 9606 (Homo sapiens) [Search protein sequence]
VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFI
HINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHGLKDK
ETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNI
IPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFR
NEGIDLTHNPEFTTCEFYMAYADYHDHMEITEKMVSGMVKHITGSYKVTY
HPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKIL
DDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLA
KWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGD
DEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAM
KP
3D structure
PDB6ilh Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
ChainA
Resolution2.501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
6.1.1.6: lysine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAA A E301 R323 H331 N332 F335 E339 Y341 E494 N497 Y499 E501 G550 R553 E228 R250 H258 N259 F262 E266 Y268 E421 N424 Y426 E428 G477 R480
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ilh, PDBe:6ilh, PDBj:6ilh
PDBsum6ilh
PubMed30733335
UniProtQ15046|SYK_HUMAN Lysine--tRNA ligase (Gene Name=KARS1)

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