Structure of PDB 6ijs Chain A

Receptor sequence
>6ijsA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
LNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMN
SLMMGEDKIKKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQ
VTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFM
EPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLL
QALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMS
LHPLLQEIYKDLY
3D structure
PDB6ijs Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPAR gamma phosphorylation.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A K301 L311 V315 L318 P467 L468 E471 K87 L97 V101 L104 P253 L254 E257
BS02 A9F A I281 F282 C285 R288 S289 I326 Y327 M329 L330 F360 F363 M364 H449 I67 F68 C71 R74 S75 I112 Y113 M115 L116 F146 F149 M150 H235
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6ijs, PDBe:6ijs, PDBj:6ijs
PDBsum6ijs
PubMed31371757
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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