Structure of PDB 6iiv Chain A

Receptor sequence
>6iivA (length=461) Species: 562,1501,9606 [Search protein sequence]
PADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLE
DKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRN
AYIQKYLPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGA
RRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFM
GVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWA
AALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSV
GLSFLLNTVSVATLCHVYHGMKKYTCTVCGYIYNPEDGDPDNGVNPGTDF
KDIPDDWVCPLCGVGKDQFEEVEERDSEVEMMAQALGIMVVASVCWLPLL
VFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFR
RAVLRRLQPRL
3D structure
PDB6iiv Structural basis for ligand recognition of the human thromboxane A2receptor.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A90 A T81 V85 H89 M112 G116 S181 W182 F184 W258 L294 R295 T298 Q301 T173 V177 H181 M204 G208 S273 W274 F276 W396 L432 R433 T436 Q439 PDBbind-CN: -logKd/Ki=6.85,Ki=140nM
BS02 ZN A C2006 C2009 C2039 C2042 C326 C329 C359 C362
BS03 CLR A R103 F107 L161 L168 R195 F199 L253 L260
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004960 thromboxane receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
GO:0043448 alkane catabolic process
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6iiv, PDBe:6iiv, PDBj:6iiv
PDBsum6iiv
PubMed30510189
UniProtP00268|RUBR_CLOPA Rubredoxin;
P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P21731|TA2R_HUMAN Thromboxane A2 receptor (Gene Name=TBXA2R)

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