Structure of PDB 6iin Chain A

Receptor sequence
>6iinA (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
MELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQ
YITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDA
NECWIQMMRVLQQKLEAIEKSLIDQFFGVEFETTMKCTESEEEEVTKGKE
NQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRL
PAYLTIQMVRFFYNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKD
LYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIK
FDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRV
3D structure
PDB6iin Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade.
ChainA
Resolution2.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A8O A Q197 Q198 D199 F331 H426 S431 S432 Y436 Y476 Q97 Q98 D99 F211 H277 S282 S283 Y287 Y327 PDBbind-CN: -logKd/Ki=6.08,IC50=0.83uM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6iin, PDBe:6iin, PDBj:6iin
PDBsum6iin
PubMed30254335
UniProtP54578|UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 (Gene Name=USP14)

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