Structure of PDB 6iil Chain A

Receptor sequence
>6iilA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQY
ITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDAN
ECWIQMMRVLQQKLEAIEDKSLIDQFFGVEFETTMKCTESEEEEVTKGKE
NQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRL
PAYLTIQMVRFFNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDL
EDKKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDE
WIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEI
3D structure
PDB6iil Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A8F A Q197 Q198 D199 F331 H426 S431 S432 Y436 Y476 Q96 Q97 D98 F211 H280 S285 S286 Y290 Y330 MOAD: ic50=0.68uM
PDBbind-CN: -logKd/Ki=6.17,IC50=0.68uM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6iil, PDBe:6iil, PDBj:6iil
PDBsum6iil
PubMed30254335
UniProtP54578|UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 (Gene Name=USP14)

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