Structure of PDB 6iid Chain A

Receptor sequence
>6iidA (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
EKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDA
DRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAET
FYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGD
GKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIG
FQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEF
TLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEE
3D structure
PDB6iid A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
ChainA
Resolution2.986 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C55 A83 N105 N114 E122
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R109 S137 R138 G139 A144 G145 K148 F168 N171 S172 N176 M180 R183 L311 R314 R52 S80 R81 G82 A87 G88 K91 F111 N114 S115 N119 M123 R126 L254 R257 PDBbind-CN: Kd=1.03uM
BS02 dna A K113 K115 S172 L311 R320 R324 K56 K58 S115 L254 R263 R267 PDBbind-CN: Kd=1.03uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6iid, PDBe:6iid, PDBj:6iid
PDBsum6iid
PubMed30949702
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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