Structure of PDB 6ihh Chain A

Receptor sequence

>6ihhA (length=249) Species: 54061 (Ralstonia sp.) [Search protein sequence]

MYRLLNKTAVITGGNSGIGLATAKRFVAEGAYVFIVGRRRKELEQAAAEI
GRNVTAVKADVTKLEDLDRLYAIVREQRGSIDVLFANSGAVEQKTLEEIT
PEHYDRTFDVNVRGLIFTVQKALPLLRDGGSVILTSSVAGVLGLQAHDTY
SAAKAAVRSLARTWTTELKGRSIRVNAVSPGAIDTPSLENNVSTQEEADE
LRAKAAAATPLGRVGRPEELAAAVLFLASDDSSYVAGIELFVDGGLTQV

3D structure

PDB

6ihh Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	G13 N15 S16 G17 I18 R38 R39 D60 V61 N87 S88 G89 V110 T135 S137 Y150 K154 P180 G181 A182 I183 T185 S187	G13 N15 S16 G17 I18 R38 R39 D60 V61 N87 S88 G89 V110 T135 S137 Y150 K154 P180 G181 A182 I183 T185 S187
BS02	A6O	A	S137 H147 Y150 L188 L246	S137 H147 Y150 L188 L246

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

View graph for
Molecular Function

External links

PDB	RCSB:6ihh, PDBe:6ihh, PDBj:6ihh
PDBsum	6ihh
PubMed
UniProt	C0IR58

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