Structure of PDB 6ih1 Chain A

Receptor sequence
>6ih1A (length=237) Species: 345073 (Vibrio cholerae O395) [Search protein sequence]
SLDFDFTMAFQPIVNCRTKEIFGYEALVRGLNNESAYSVISRVNEDNRYL
FDQMCRVKAIALAAKLGLTSKLSINFLPNAIYVPERCIRTTLEAAKRYQF
PIENIMFEFTEAERVEDVNHIKRIVEYYKSLGFQTAIDDFGSGYSGLNLL
ADFQTNIVKVDMGLIRNIHADQVRQSIMKNCLKLFSDLNIQPLAEGVESH
AEFAWLKAAGVELMQGYYFAKPGFESLPSVNPEFSEA
3D structure
PDB6ih1 Structures of c-di-GMP/cGAMP degrading phosphodiesterase VcEAL: identification of a novel conformational switch and its implication.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.52: cyclic-guanylate-specific phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2E A Q31 L47 V48 R49 I60 C75 N95 L97 M182 G216 E218 G236 Y237 Q11 L27 V28 R29 I40 C55 N75 L77 M162 G196 E198 G216 Y217
BS02 CA A E45 N95 E128 D158 E25 N75 E108 D138
BS03 CA A D158 D159 E215 D138 D139 E195
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6ih1, PDBe:6ih1, PDBj:6ih1
PDBsum6ih1
PubMed31647518
UniProtA0A0H3AJ04

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