Structure of PDB 6ig0 Chain A

Receptor sequence

>6ig0A (length=737) Species: 767463 (Streptococcus thermophilus ND03)

KKEKIDLFYGALLHNIGKVIQRATGERKKHALVGADWFDEIADNQVISDQ
IRYHMANYQSDKLDHLAYITYIADNIASGVDRTYTNQADIFNVFGAQTDK
RYFKPTVLNLKSKPNFASATYEPFSKGDYAAIATRIKNELAEFEFNQVQI
DSLLNLFEATLSFVPSSTNTKEIADISLADHSRLTAAFALAIYDYLEDKG
RHNYKEDLFTKVSAFYEEEAFLLASFDLSGIQDFIYNINIATNGAAKQLK
ARSLYLDFMSEYIADSLLDKLGLNRANMLYVGGGHAYFVLANTEKTVETL
VQFEKDFNQFLLANFQTRLYVAFGWGSFAAKDIMSELNSPESYRQVYQKA
SRMISKKKISRYDYQTLMLLNRGGKSSERECEICHSVENLVSYHDQKVCD
ICRGLYQFSKEIAHDHFIITENEGLPIGPNACLKGVAFEKLSQEAFSRVY
VKNDYKAGTVKATHVFVGDYQCDEIYNYAALSKNENGLGIKRLAVVRLDV
DDLGAAFMAGFSQQGNGQYSTLSRSATFSRSMSLFFKVYINQFASDKKLS
IIYAGGDDVFAIGSWQDIIAFTVELRENFIKWTNGKLTLSAGIGLFADKT
PISLMAHQTGELEEAAKGNEKDSISLFSSDYTFKFDRFITNVYDDKLEQI
RYFFNHQDERGKNFIYKLIELLRNHDRMNMARLAYYLTRLEELTRETDRD
KFKTFKNLFYSWYTNKNDKDRKEAELALLLYIYEIRK

3D structure

• PDB: 6ig0 Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference
• Chain: A
• Resolution: 3.37 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	E400 H405	E380 H385
BS02	rna	A	A261 T262 N263 G264 A265 K267 H414 Y496 R512 K619 P621 R680 G681 K682 N683 Y686 Y705 R709 R756 K757	A241 T242 N243 G244 A245 K247 H394 Y476 R492 K599 P601 R660 G661 K662 N663 Y666 Y685 R689 R736 K737
BS03	ZN	A	C404 C419 C422	C384 C399 C402
BS04	ATP	A	D247 I251 Q252 G303 H305 K378 Y573 D577	D227 I231 Q232 G283 H285 K358 Y553 D557
BS05	ATP	A	Y300 D519 V520 D521 D522 L523 G524 F527 M528 D577 K637	Y280 D499 V500 D501 D502 L503 G504 F507 M508 D557 K617
BS06	MG	A	D519 D577	D499 D557
BS07	MG	A	D519 D577	D499 D557

External links

• PDB: RCSB:6ig0, PDBe:6ig0, PDBj:6ig0
• PDBsum: 6ig0
• PubMed: 30503210