Structure of PDB 6ifk Chain A

Receptor sequence

>6ifkA (length=734) Species: 767463 (Streptococcus thermophilus ND03) [Search protein sequence]

KKEKIDLFYGALLHNIGKVIQRATGERKKHALVGADWFDEIADNQVISDQ
IRYHMANYQSDKLDHLAYITYIADNIASGVDRTYTNQADIFNVFGAQTDK
RYFKPTVLNLKSKPNFASATYEPFSKGDYAAIATRIKNELAEFEFNQVQI
DSLLNLFEATLSFVPSSTNTKEIADISLADHSRLTAAFALAIYDYLEDKG
RHNYKEDLFTKVSAFYEEEAFLLASFDLSGIQDFIYNINIATNGAAKQLK
ARSLYLDFMSEYIADSLLDKLGLNRANMLYVGGGHAYFVLANTEKTVETL
VQFEKDFNQFLLANFQTRLYVAFGWGSFAAKDIMNSPESYRQVYQKASRM
ISKKKISRYDYQTLMLLNRGGKSSERECEICHSVENLVSYHDQKVCDICR
GLYQFSKEIAHDHFIITENEGLPIGPNACLKGVAFEKLSQEAFSRVYVKN
DYKAGTVKATHVFVGDYQCDEIYNYAALSKNENGLGIKRLAVVRLDVDDL
GAAFMAGFSQQGNGQYSTLSRSATFSRSMSLFFKVYINQFASDKKLSIIY
AGGDDVFAIGSWQDIIAFTVELRENFIKWTNGKLTLSAGIGLFADKTPIS
LMAHQTGELEEAAKGNEKDSISLFSSDYTFKFDRFITNVYDDKLEQIRYF
FNHQDERGKNFIYKLIELLRNHDRMNMARLAYYLTRLEELTRETDRDKFK
TFKNLFYSWYTNKNDKDRKEAELALLLYIYEIRK

3D structure

PDB

6ifk Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	E400 H405	E377 H382
BS02	rna	A	A261 T262 N263 A265 H414 K511 R512 K619 R680 G681 K682 N683 Y686 Y705 R709 R756	A241 T242 N243 A245 H391 K488 R489 K596 R657 G658 K659 N660 Y663 Y682 R686 R733
BS03	ANP	A	Y300 H305 D519 V520 D521 D522 L523 F527 S549 G576 K637 K641	Y280 H285 D496 V497 D498 D499 L500 F504 S526 G553 K614 K618
BS04	ANP	A	D247 I251 Q252 I255 S273 G303 K378 Y573	D227 I231 Q232 I235 S253 G283 K355 Y550
BS05	MG	A	D519 V520	D496 V497
BS06	MG	A	D519 D577	D496 D554
BS07	ZN	A	C404 C422	C381 C399

External links

PDB	RCSB:6ifk, PDBe:6ifk, PDBj:6ifk
PDBsum	6ifk
PubMed	30503210

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