Structure of PDB 6icv Chain A

Receptor sequence

>6icvA (length=480) Species: 9606 (Homo sapiens)

SPKEILNLTSELLQKCSSPAPGKEWEEYVQIRTLVEKIRKKQKGLSVTFD
GKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLW
VPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFW
QPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYK
VIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIP
LWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFV
IHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHF
TEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDN
EVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEK
EILEKAVKSAAVNREYYRQQMEEKAPLPKY

3D structure

• PDB: 6icv Structural insights into SETD3-mediated histidine methylation on beta-actin.
• Chain: A
• Resolution: 2.15 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.85: protein-histidine N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	S37 M152 N154 I155 R215 Q216 V248 V251 Q255 N256 P259 W274 D275 T286 G287 Y288 Y313 R316 H324	S17 M130 N132 I133 R193 Q194 V226 V229 Q233 N234 P237 W252 D253 T264 G265 Y266 Y291 R294 H302
BS02	SAH	A	R75 E104 F106 T253 R254 D275 M276 N278 H279 Y313 S325 F327	R53 E82 F84 T231 R232 D253 M254 N256 H257 Y291 S303 F305

Gene Ontology

Molecular Function

• GO:0018064 protein-L-histidine N-tele-methyltransferase activity

Biological Process

• GO:0030047 actin modification

External links

• PDB: RCSB:6icv, PDBe:6icv, PDBj:6icv
• PDBsum: 6icv
• PubMed: 30785395
• UniProt: Q86TU7|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)