Structure of PDB 6icj Chain A

Receptor sequence
>6icjA (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTKSPFVIYDMNSLMM
GEKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV
HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV
KFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLK
LNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEI
YKDL
3D structure
PDB6icj Crystal structure of PPARgamma with compound BR102375K
ChainA
Resolution2.483 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 Q314 V315 K319 L468 E471 K79 Q92 V93 K97 L246 E249
BS02 A0L A I281 F282 C285 R288 S289 A292 M329 L330 F363 M364 H449 L465 Y473 I59 F60 C63 R66 S67 A70 M107 L108 F141 M142 H227 L243 Y251 BindingDB: EC50=280nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6icj, PDBe:6icj, PDBj:6icj
PDBsum6icj
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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