Structure of PDB 6ic5 Chain A

Receptor sequence
>6ic5A (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]
DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTA
YDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTG
WVHDVLGRNWACFTGKKV
3D structure
PDB6ic5 Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.1: dipeptidyl-peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HB5 A D1 P3 D1 P3 PDBbind-CN: -logKd/Ki=8.22,IC50=6nM
External links
PDB RCSB:6ic5, PDBe:6ic5, PDBj:6ic5
PDBsum6ic5
PubMed30978322
UniProtP53634|CATC_HUMAN Dipeptidyl peptidase 1 (Gene Name=CTSC)

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