Structure of PDB 6iar Chain A

Receptor sequence
>6iarA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TFSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLI
LSHIRHMSNKGMEHLYSMKCKNVVPSYDLLLEMLDAH
3D structure
PDB6iar Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.
ChainA
Resolution1.84 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H8W A L346 T347 E353 L387 M421 V533 V534 L37 T38 E44 L78 M112 V223 V224 PDBbind-CN: -logKd/Ki=7.60,IC50=25.1nM
External links
PDB RCSB:6iar, PDBe:6iar, PDBj:6iar
PDBsum6iar
PubMed30640465
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]