Structure of PDB 6iao Chain A

Receptor sequence
>6iaoA (length=455) Species: 1404 (Priestia megaterium) [Search protein sequence]
KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGLVTRYL
SSQRLIKEACDGSRFDKNLSQALKFVRDIAGDGLVTSWTHEKNWKKAHNI
LLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPGDMTRLTLDT
IGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKQQRANPDDPACDENK
RQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDE
NIRYQIITFLIAGHVTTSGLLSFALYFLVKNPYVLQKAAEEAARVLVDPV
PSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDE
LMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIG
QQFALHEATLVLSMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKK
IPLGG
3D structure
PDB6iao Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol.
ChainA
Resolution2.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
1.6.2.4: NADPH--hemoprotein reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A K69 L86 V87 W96 F261 A264 G265 T268 F331 P392 F393 R398 C400 I401 G402 A406 K67 L84 V85 W94 F259 A262 G263 T266 F329 P390 F391 R396 C398 I399 G400 A404
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:6iao, PDBe:6iao, PDBj:6iao
PDBsum6iao
PubMed31125381
UniProtP14779|CPXB_PRIM2 Bifunctional cytochrome P450/NADPH--P450 reductase (Gene Name=cyp102A1)

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