Structure of PDB 6ia7 Chain A

Receptor sequence
>6ia7A (length=153) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
LVKILVLGPSKSGKSTVTNFLAGTRETNPLRVLEVEIALDAVVQLWDVGG
WPAIASNADGIIYVFNPEVKGSEKELLLWYKNFARVTDGHSLIFSHHSSL
PEFAVGDNAIPPMPKQLQGIRALETSLDYQSDNFKEAFDALVEQIIASRL
AAE
3D structure
PDB6ia7 Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A S14 K15 S16 G17 K18 S19 T20 T39 H143 S145 L174 D175 Y176 S10 K11 S12 G13 K14 S15 T16 T27 H96 S98 L127 D128 Y129 PDBbind-CN: -logKd/Ki=5.70,Kd=2uM
BS02 MG A S19 D73 S15 D47
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006886 intracellular protein transport
GO:0060271 cilium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0012505 endomembrane system
GO:0030992 intraciliary transport particle B
GO:0031514 motile cilium
GO:0036064 ciliary basal body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ia7, PDBe:6ia7, PDBj:6ia7
PDBsum6ia7
PubMed30940671
UniProtQ381A3|IFT22_TRYB2 Intraflagellar transport protein 22 (Gene Name=IFT22)

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