Structure of PDB 6i8z Chain A

Receptor sequence
>6i8zA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS
VREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV
RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLG
DFGLSRLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVK
NNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLS
TILEEEKAQQE
3D structure
PDB6i8z Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions.
ChainA
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 R550 N551 D564
Catalytic site (residue number reindexed from 1) D133 R137 N138 D151
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H82 A I428 A452 M499 E500 L501 C502 T503 G505 E506 L553 G563 D564 L567 I15 A39 M86 E87 L88 C89 T90 G92 E93 L140 G150 D151 L154 MOAD: ic50=17nM
PDBbind-CN: -logKd/Ki=7.80,IC50=15.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6i8z, PDBe:6i8z, PDBj:6i8z
PDBsum6i8z
PubMed30739444
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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