Structure of PDB 6i7k Chain A

Receptor sequence
>6i7kA (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
SLEARAALNQALEMKRQGKREKAQKLFMHALKMDPDFVDALTEFGIFSEE
DKDIIQADYLYTRALTISPYHEKALVNRDRTLPLVEEIDQRYFSIIDSKV
KKVMSIPKGNSALRRVMEETYYHHIYHTVAIEGNTLTLSEIRHILETRYA
VPGKSDEEQNEVIGMHAAMKYINTTLVSRIGSVTISDVLEIHRRVLGYVD
PVEAGRFRTTQVLVGHHIPPHPQDVEKQMQEFVQWLNSEEAMNLHPVEFA
ALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIRKEQRSDYYHV
LEAANEGDVRPFIRFIAKCTETTLDTLLFATTE
3D structure
PDB6i7k An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.
ChainA
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.108: protein adenylyltransferase.
3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A E234 V316 H319 V360 H363 D367 G368 N369 G370 R371 R374 Y399 Y400 N407 E132 V214 H217 V258 H261 D265 G266 N267 G268 R269 R272 Y297 Y298 N305
External links
PDB RCSB:6i7k, PDBe:6i7k, PDBj:6i7k
PDBsum6i7k
PubMed31531998
UniProtQ9BVA6|FICD_HUMAN Protein adenylyltransferase FICD (Gene Name=FICD)

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