Structure of PDB 6i7g Chain A

Receptor sequence
>6i7gA (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
EARAALNQALEMKRQGKREKAQKLFMHALKMDPDFVDALTEFGIFSEEDK
DIIQADYLYTRALTISPYHEKALVNRDRTLPLVEEIDQRYFSIIDSKVKK
VMSIPKGNSALRRVMEETYYHHIYHTVAIEGNTLTLSEIRHILETRYAVP
GKSLEEQNEVIGMHAAMKYINTTLVSRIGSVTISDVLEIHRRVLGYVDPV
EAGRFRTTQVLVGHHIPPHPQDVEKQMQEFVQWLNSEEAMNLHPVEFAAL
AHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIRKEQRSDYYHVLE
AANEGDVRPFIRFIAKCTETTLDTLLFAT
3D structure
PDB6i7g An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.108: protein adenylyltransferase.
3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A E234 V316 H319 V360 H363 G368 N369 G370 R371 Y399 Y400 L403 N407 E130 V212 H215 V256 H259 G264 N265 G266 R267 Y295 Y296 L299 N303
External links
PDB RCSB:6i7g, PDBe:6i7g, PDBj:6i7g
PDBsum6i7g
PubMed31531998
UniProtQ9BVA6|FICD_HUMAN Protein adenylyltransferase FICD (Gene Name=FICD)

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