Structure of PDB 6i7b Chain A

Receptor sequence

>6i7bA (length=382) Species: 381518 (Influenza A virus (A/Wilson-Smith/1933(H1N1)))

NATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSA
FDTGGPIYRRVDGKWRRELILYDKEEIRRIWRQANNGDDATAGLTHMMIW
HSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTM
VMELIRMIKRGINRRTRIAYERMCNILKGKFQTAAQRTMVDQVRESRNPG
NAEFEDLIFLARSALILRGSVAHKSCLPACVYGSAVASGYDFEREGYSLV
GIDPFRLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRG
TKVVPRGKLSTRGVQIASNENMETMESSTLELRSRYWAIRTRSGGNTDVS
FQGRGVFELSDEKATSPIVPSFDMSNEGSYFF

3D structure

• PDB: 6i7b Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
• Chain: A
• Resolution: 10.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R162 S165 L264 I265 R267 H272 S335 F338 E339 D340 R342 I347 A387 I388 R389 T390 S457 F458 Q459 G460 R461 G462 P477 S486 Y487 F489	R123 S126 L215 I216 R218 H223 S286 F289 E290 D291 R293 I298 A338 I339 R340 T341 S350 F351 Q352 G353 R354 G355 P370 S379 Y380 F382

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005198 structural molecule activity

Biological Process

• GO:0039689 negative stranded viral RNA replication
• GO:0046718 symbiont entry into host cell
• GO:0075732 viral penetration into host nucleus

Cellular Component

• GO:0019013 viral nucleocapsid
• GO:0019029 helical viral capsid
• GO:0042025 host cell nucleus
• GO:0043657 host cell
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6i7b, PDBe:6i7b, PDBj:6i7b
• PDBsum: 6i7b
• PubMed: 32152587
• UniProt: P15682|NCAP_I33A0 Nucleoprotein (Gene Name=NP)