Structure of PDB 6i6m Chain A

Receptor sequence
>6i6mA (length=343) Species: 3469 (Papaver somniferum) [Search protein sequence]
VCYLSETANLGKLICIPMALRAAMELNVFQLISKFGTDAKVSASEIASKM
PNAKNNPEAAMYLDRILRLLGASSILSVSTEKLYGLTNSSCCLVPRQEDG
VSLVEELLFTSDKVVVDSFFKLKCVVEEKDSVPFEVAHGAKIFEYAATEP
RMNQVFNDGMAVFSIVVFEAVFRVYDGFLDMKELLDVGGGIGTSVSKIVA
KYPLIRGVNFDLPHVISVAPQYPGVEHVAGDMFEEVPKGQNMLLKWVLHA
WGDERCVKLLKNCWNSLPVGGKVLIIEFVLPNELGNNAESFNALIPDLLL
MALNPGGKERTISEYDDLGKAAGFIKTIPIPISNGLHVIEFHK
3D structure
PDB6i6m Structure of Papaver somniferum O-Methyltransferase 1 Reveals Initiation of Noscapine Biosynthesis with Implications for Plant Natural Product Methylation
ChainA
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.117: (S)-scoulerine 9-O-methyltransferase.
2.1.1.89: tetrahydrocolumbamine 2-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SLX A E153 T157 F203 M207 F210 W293 H296 F325 N339 I342 P343 L347 E106 T110 F156 M160 F163 W246 H249 F278 N292 I295 P296 L300
BS02 SAH A F190 M207 S211 G235 D258 L259 M279 K292 W293 F143 M160 S164 G188 D211 L212 M232 K245 W246
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0030762 tetrahydrocolumbamine 2-O-methyltransferase activity
GO:0030777 (S)-scoulerine 9-O-methyltransferase activity
GO:0046983 protein dimerization activity
Biological Process
GO:0009708 benzyl isoquinoline alkaloid biosynthetic process
GO:0009820 alkaloid metabolic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6i6m, PDBe:6i6m, PDBj:6i6m
PDBsum6i6m
PubMed
UniProtI3V6A7|SOMT1_PAPSO Scoulerine-9-O-methyltransferase 1 (Gene Name=SOMT1)

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