Structure of PDB 6i65 Chain A

Receptor sequence
>6i65A (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
YNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWA
KHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMD
EDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIE
DVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQ
HFYNIKLEGKVPMHKLFLEMLEAK
3D structure
PDB6i65 Insights into the activation mechanism of human estrogen-related receptor gamma by environmental endocrine disruptors.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H3Z A E275 L309 V313 Y326 F435 E42 L76 V80 Y93 F202 MOAD: Kd=390.4nM
PDBbind-CN: -logKd/Ki=6.41,Kd=390.4nM
External links
PDB RCSB:6i65, PDBe:6i65, PDBj:6i65
PDBsum6i65
PubMed31127318
UniProtP62508|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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