Structure of PDB 6i5j Chain A

Receptor sequence
>6i5jA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSD
YLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY
VQMCKDKRGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWG
LPLPTRLKDYLEEYKFQV
3D structure
PDB6i5j Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R73 S75 S76 A90 G91 P92 T93 N94 L95 R96 D107 S108 I109 I110 R44 S46 S47 A61 G62 P63 T64 N65 L66 R67 D78 S79 I80 I81
BS02 peptide A Y128 M132 X133 K136 R137 T147 V148 H149 Y99 M103 X104 K107 R108 T117 V118 H119
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:6i5j, PDBe:6i5j, PDBj:6i5j
PDBsum6i5j
PubMed31182716
UniProtO14508|SOCS2_HUMAN Suppressor of cytokine signaling 2 (Gene Name=SOCS2)

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