Structure of PDB 6i4i Chain A

Receptor sequence
>6i4iA (length=352) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
VQALVVDNGSGNVKAGVAGDDAPRSVFPSIVGRPKNPDAYVGDEAQTKRG
ILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEHPVLLTEAPLNPK
GNRERMTQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVSHTV
PIYEGYALPHAIMRLDLAGRDLTEYLMKILHERGYGFSTSAEKEIVRDIK
EKLCYIALNFDEEMKTSEQSSDIEKSYELPDGNIITVGNERFRCPEALFQ
PSFLGKEAAGIHTTTFNSIKKCDVDIRKDLYGNIVLSGGTTMYEGIGERL
TRDITTLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITKEEYD
ES
3D structure
PDB6i4i Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G14 G16 N17 K19 G157 D158 G183 R211 K214 E215 G302 G303 T304 M306 Y307 K337 G9 G11 N12 K14 G143 D144 G169 R197 K200 E201 G288 G289 T290 M292 Y293 K323
BS02 AF3 A S15 G157 D158 V160 S10 G143 D144 V146
BS03 K A D155 S156 G157 V160 S161 D141 S142 G143 V146 S147
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0007010 cytoskeleton organization
GO:0009665 plastid inheritance
GO:0020014 schizogony
GO:0070360 symbiont-mediated actin polymerization-dependent cell-to-cell migration in host
GO:0085017 entry into host cell by a symbiont-containing vacuole
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0015629 actin cytoskeleton

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Molecular Function
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Cellular Component
External links
PDB RCSB:6i4i, PDBe:6i4i, PDBj:6i4i
PDBsum6i4i
PubMed31199804
UniProtQ8I4X0|ACT1_PLAF7 Actin-1 (Gene Name=ACT1)

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