Structure of PDB 6i4d Chain A

Receptor sequence

>6i4dA (length=351) Species: 36329 (Plasmodium falciparum 3D7)

DVQALVVDNGSGNVKAGVAGDDAPRSVFPSIVGRPKDAFVGDEAQTKRGI
LTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEHPVLLTEAPLNPKG
NRERMTQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVSHTVP
IYEGYALPHAIMRLDLAGRDLTEYLMKILHERGYGFSTSAEKEIVRDIKE
KLCYIALNFDEEMKTSEQSSDIEKSYELPDGNIITVGNERFRCPEALFQP
SFLGKEAAGIHTTTFNSIKKCDVDIRKDLYGNIVLSGGTTMYEGIGERLT
RDITTLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITKEEYDE
S

3D structure

• PDB: 6i4d Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation.
• Chain: A
• Resolution: 1.24 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	G14 S15 G16 N17 K19 G157 D158 G159 V160 G183 R211 K214 E215 G302 G303 T304 M306 Y307	G10 S11 G12 N13 K15 G142 D143 G144 V145 G168 R196 K199 E200 G287 G288 T289 M291 Y292
BS02	ADP	A	G14 G16 N17 K19 G157 D158 G183 K214 E215 G303 T304 M306 Y307	G10 G12 N13 K15 G142 D143 G168 K199 E200 G288 T289 M291 Y292
BS03	K	A	D155 S156 G157 V160 S161	D140 S141 G142 V145 S146

Gene Ontology

Molecular Function

• GO:0005200 structural constituent of cytoskeleton
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0007010 cytoskeleton organization
• GO:0009665 plastid inheritance
• GO:0020014 schizogony
• GO:0070360 symbiont-mediated actin polymerization-dependent cell-to-cell migration in host
• GO:0085017 entry into host cell by a symbiont-containing vacuole

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005884 actin filament
• GO:0015629 actin cytoskeleton

External links

• PDB: RCSB:6i4d, PDBe:6i4d, PDBj:6i4d
• PDBsum: 6i4d
• PubMed: 31199804
• UniProt: Q8I4X0|ACT1_PLAF7 Actin-1 (Gene Name=ACT1)