Structure of PDB 6i3c Chain A

Receptor sequence
>6i3cA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
GDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVD
AVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQR
MVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDT
LLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYR
EVVDGLEKAIYKGP
3D structure
PDB6i3c Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase.
ChainA
Resolution1.336 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.6: catechol O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D141 D169 N170 D140 D168 N169
BS02 SAM A M40 V42 G66 Y68 S72 E90 I91 S119 D141 H142 W143 M39 V41 G65 Y67 S71 E89 I90 S118 D140 H141 W142
BS03 DNC A W38 W143 K144 N170 P174 E199 W37 W142 K143 N169 P173 E198
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
Biological Process
GO:0006584 catecholamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6i3c, PDBe:6i3c, PDBj:6i3c
PDBsum6i3c
PubMed31080692
UniProtP21964|COMT_HUMAN Catechol O-methyltransferase (Gene Name=COMT)

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