Structure of PDB 6i34 Chain A

Receptor sequence
>6i34A (length=953) Species: 63221 (Homo sapiens neanderthalensis) [Search protein sequence]
ASRLLERLLPRHDDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPAN
IRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYNCSVPQTIL
RNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLD
EGTAAAEALQLCYRHNKRRKFFVDPRCHPQTIAVVQTRAKYTGVLTELKL
PCEMDFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLA
LCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRM
VGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIY
HGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCGCSVKE
VLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVA
ESMRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSM
IPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDL
CELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHG
TNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYPST
NGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNL
HKTFCIPHGGGGPGMGPIGVKKHLAPFLPNHPVISLKRNEDACPVGTVSA
APWGSSSILPISWAYIKMMGGKGLKQATETAILNANYMAKRLETHYRILF
RGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGT
LMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSL
TCVTSSHWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTC
PPM
3D structure
PDB6i34 Structural insights in human glycine decarboxylase and comparison with the Neanderthal variant
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.4.2: glycine dehydrogenase (aminomethyl-transferring).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A C382 T383 S557 G618 A619 H651 D727 A729 N751 H753 K754 C334 T335 S505 G566 A567 H599 D675 A677 N699 H701 K702
Gene Ontology
Molecular Function
GO:0004375 glycine dehydrogenase (decarboxylating) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016594 glycine binding
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0070280 pyridoxal binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0006544 glycine metabolic process
GO:0006546 glycine catabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system
GO:0036255 response to methylamine
GO:1903442 response to lipoic acid
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0005960 glycine cleavage complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6i34, PDBe:6i34, PDBj:6i34
PDBsum6i34
PubMed
UniProtP23378|GCSP_HUMAN Glycine dehydrogenase (decarboxylating), mitochondrial (Gene Name=GLDC)

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