Structure of PDB 6i2r Chain A

Receptor sequence
>6i2rA (length=824) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
EDKNARVIELIAAYRNRGHLMADIDPLRLDNTRFLTLWDLDREFKVDVQR
KKLRDILSVLRDAYCRHVGVEYTHILEPEQQRWIQERVETKHDKPTVAEQ
KYILSKLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAVIDQCAEHG
LDEVVIAMPHRGRLNVLANIVGKPYSQIFSEFESGDVKYHLGATGTYIQM
FGDNDIEVSLTANPSHLEAVDPVLEGLVRAKQDLLDTGEEGSDNRFSVVP
LMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHIVVNNQIGFTTAPTDS
RSSEYCTDVAKMIGAPIFHVNGDDPEACAWVARLAVDFRQAFKKDVVIDM
LCYRRRGHNEGDDPSMTQPYMYDVIDTKRGSRKAYTEALIGRGDISMKEA
EDALRDYQGQLEAVFNEVRELEKHPSKLATAVDKAMLQRIGDAHLALPEG
FTVHPRVRPVLEKRREMAYEGRIDWAFAELLALGSLIAEGKLVRLSGQDT
QRGTFTQRHAVIVDRKTGEEFTPLQLLATNPDGTPTGGKFLVYNSALSEF
AAVGFEYGYSVGNPDAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLS
DVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIAMPSTPANYFHLLR
RHGKDGIQRPLIVFTPKSMLRNKAAVSDIRDFTESKFRSVLEEPMYTDGE
GDRNKVTRLLLTSGKIYYELAARKAKENREDVAIVRIEQLAPLPRRRLAE
TLDRYPNVKEKFWVQEEPANQGAWPSFGLTLPEILPDHFTGLKRISRRAM
SAPSSGSSKVHAVEQQEILDTAFG
3D structure
PDB6i2r Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
ChainA
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring).
2.2.1.5: 2-hydroxy-3-oxoadipate synthase.
2.3.1.61: dihydrolipoyllysine-residue succinyltransferase.
4.1.1.71: 2-oxoglutarate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP A R540 S604 L606 G644 D645 A646 A647 N678 I680 H747 R161 S215 L217 G255 D256 A257 A258 N289 I291 H358
BS02 MG A D645 N678 I680 D256 N289 I291
BS03 CA A D1004 H1055 D1058 I1060 D601 H652 D655 I657
BS04 TPP A Q901 L950 E952 Q976 F980 Q498 L547 E549 Q573 F577
Gene Ontology
Molecular Function
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding

View graph for
Molecular Function
External links
PDB RCSB:6i2r, PDBe:6i2r, PDBj:6i2r
PDBsum6i2r
PubMed31064884
UniProtA0R2B1|KGD_MYCS2 Multifunctional 2-oxoglutarate metabolism enzyme (Gene Name=kgd)

[Back to BioLiP]