Structure of PDB 6i2q Chain A

Receptor sequence
>6i2qA (length=824) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
DSIEDKNARVIELIAAYRNRGHLMADIDPLRLDNTRFSHGLTLWDLDREF
KVVQRKKLRDILSVLRDAYCRHVGVEYTHILEPEQQRWIQERVETKHDKP
TVAEQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAVIDQ
CAEHGLDEVVIAMPHRGRLNVLANIVGKPYSQIFSEFGDVKYHLGATGTY
IQMFGDNDIEVSLTANPSHLEAVDPVLEGLVRAKQDLLDTGEEGSDNRFS
VVPLMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHIVVNNQIGFTTAP
TDSRSSEYCTDVAKMIGAPIFHVNGDDPEACAWVARLAVDFRQAFKKDVV
IDMLCYRRRGHNEGDDPSMTQPYMYDVIDTKRGSRKAYTEALIGRGDISM
KEAEDALRDYQGQLERVFNEVRELEKHLATAVDKAMLQRIGDAHLALPEG
FTVHPRVRPVLEKRREMAYEGRIDWAFAELLALGSLIAEGKLVRLSGQDT
QRGTFTQRHAVIVDRKTGEEFTPLQLLATNPDGTPTGGKFLVYNSALSEF
AAVGFEYGYSVGNPDAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLS
DVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIAMPSTPANYFHLLR
RHGKDGIQRPLIVFTPKSMLRNKAAVSDIRDFTESKFRSVLEEPMYTDGE
GDRNKVTRLLLTSGKIYYELAARKAKENREDVAIVRIEQLAPLPRRRLAE
TLDRYPNVKEKFWVQEEPANQGAWPSFGLTLPEILPDHFTGLKRISRRAM
SAPSSGSSKVHAVEQQEILDTAFG
3D structure
PDB6i2q Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring).
2.2.1.5: 2-hydroxy-3-oxoadipate synthase.
2.3.1.61: dihydrolipoyllysine-residue succinyltransferase.
4.1.1.71: 2-oxoglutarate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP A R540 S604 L606 G644 D645 A646 A647 Q651 N678 I680 H747 R166 S218 L220 G258 D259 A260 A261 Q265 N292 I294 H361
BS02 MG A D645 N678 I680 D259 N292 I294
BS03 CA A D1004 H1055 D1058 I1060 D601 H652 D655 I657
Gene Ontology
Molecular Function
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding

View graph for
Molecular Function
External links
PDB RCSB:6i2q, PDBe:6i2q, PDBj:6i2q
PDBsum6i2q
PubMed31064884
UniProtA0R2B1|KGD_MYCS2 Multifunctional 2-oxoglutarate metabolism enzyme (Gene Name=kgd)

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